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. 2024 Dec 7;17(12):101008. doi: 10.1016/j.waojou.2024.101008

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© 2024 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Fig. 2 — Causal effect of gene expression in blood on asthma. SMR, Summary Data-based Mendelian Randomization; TSMR: Two-Sample Mendelian Randomization; eQTL, expression quantitative trait loci; OR, odds ratio; CI, confidence interval; _S, by using SMR; _T, by using TSMR; Discovery, exposure from eQTLGen, and outcome from UK Biobank (UKB); Finngen, exposure from Gtex and outcome from Finngen; TAGC, exposure from Gtex and outcome from Trans-National Asthma Genetic Consortium (TAGC); F_T, meta-analysis of results from Gtex→Finngen and Gtex→TAGC; Finngen_2, exposure from eQTLGen and outcome from Finngen; TAGC, exposure from eQTLGen and outcome from TAGC; F_T_2, meta-analysis of results from eQTLGen→Finngen and eQTLGen→TAGC.