Table 1.
Mendelian randomization analysis results for causal genes and methylation sites of asthma, along with corresponding pathways.
| Methylation sites (blood) → Asthma |
Genes (blood) → Asthma |
Methylation sites (blood) → Genes (blood) |
Methylation sites→Genes→Asthma |
Genes (lung)→Asthma |
||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Methylation sites | OR (95% CI) | FDR | Genes | OR (95% CI) | FDR | β (95%CI) | FDR | Proportion mediated | OR (95% CI) | FDR |
| – | – | – | CEP95 | 0.94 (0.91–0.97) |
0.001 | – | – | – | 0.83 (0.75–0.92) |
<0.001 |
| – | – | – | HOXB-AS1 | 1.05 (1.03–1.07) |
<0.001 | – | – | – | 1.04 (1.01–1.08) |
0.01 |
| – | – | – | RBM6 | 0.97 (0.95–0.99) |
0.01 | – | – | – | 0.94 (0.92–0.96) |
<0.001 |
| cg16265553 ITPKB |
1.29 (1.12–1.47) |
0.004 | ITPKB | 0.82 (0.74–0.92) |
0.02 | −0.457 (−0.63 to −0.28) |
<0.001 | 35.3% | – | – |
| cg23717186 ITPKB |
1.15 (1.07–1.22) |
0.002 | – | – | – | – | – | – | – | – |
| – | – | – | ETS1 | 1.62 (1.29–2.04) |
0.001 | – | – | – | – | – |
| cg08458745 ETS1 |
0.92 (0.87–0.96) |
0.004 | – | – | – | – | – | – | – | – |
| cg14718848 ETS1 |
1.02 (1.01–1.04) |
0.004 | – | – | – | – | – | – | – | – |
| cg23774988 ETS1 |
0.85 (0.77–0.93) |
0.004 | – | – | – | – | – | – | – | – |
| cg13661497 JAK2 |
0.72 (0.59–0.88) |
0.008 | JAK2 | 1.13 (1.06–1.21) |
0.01 | −2.572 (−3.24 to −1.91) |
<0.001 | 96.7% | – | – |
| cg02405213 JAK2 |
0.97 (0.96–0.99) |
0.002 | – | – | – | – | – | – | – | – |
| cg20394284 JAK2 |
1.04 (1.02–1.07) |
0.002 | – | – | – | – | – | – | – | – |
The table was based Summary Data-based Mendelian Randomization (SMR) method in discovery phase. OR, odds ratio; CI, confidence interval