Table 2.
CORMAC core outcomes versus PLATO planned outcomes.
| Outcome domain | CORMAC core outcome | Planned PLATO outcome | |
|---|---|---|---|
| 1 | Disease activity | Treatment response | Yes |
| 2 | Local failure | Yes | |
| 3 | Regional failure | Yes | |
| 4 | Distant failure | Yes | |
| 5 | Disease progression | No | |
| 6 | Salvage surgery | Yes | |
| 7 | Survival | Overall survival | Yes |
| 8 | Cancer-specific survival | Yes | |
| 9 | Disease-free survival | ||
| 10 | Metastasis-free survival | ||
| 11 | Progression-free survival | No | |
| 12 | Toxicity | Anal incontinence | |
| 13 | Faecal urgency | ||
| 14 | Pelvic fistula | ||
| 15 | Colostomy/ileostomy | Yes | |
| 16 | Skin loss | ||
| 17 | Life impact | Physical function | Yes |
| 18 | Sexual function | Yes | |
| 19 | Health related QoL | Yes |