Table 3.
A summary of the researches on the effect of clear aligners on oral microbiome in saliva
|
Appliances |
Groups | Collection samples | Time points | Microbial detection techniques | Related parameters | Reference |
|---|---|---|---|---|---|---|
| FA CA |
FA group; CA group |
Saliva | T0 (baseline), T1 (3 months), T2 (6 months) |
Streptococcus mutans and Lactobacilli counts | PLI, salivary flow, buffering power of saliva | Mummolo et al.102 |
| FA CA |
FA group; CA group |
Saliva | T0 (baseline), T1 (3 months), T2 (6 months) |
16S rRNA sequencing | PLI, GI, PD | Wang et al.103 |
| CA | CA group | Saliva | T0 (baseline), T1 (6 months) |
16S rRNA sequencing | BOP, PLI, PD | Zhao et al.104 |
| FA CA |
FA group; CA group |
Saliva | 6 months | 16S rRNA sequencing | – | Wang et al.105 |
| CA | WSL group; Health group |
Saliva | >1 year | 16S rRNA sequencing; UPLC-MS/MS |
– | Song et al.100 |
FA: fixed appliances; CA: clear aligners; PLI: plque index; GI: gingival index; PD: probing depth; BOP: bleeding on probing; WSL: white spot lesions; UPLC-MS/MS: ultra-performance liquid chromatography-tandem mass spectrometry.