Table 3.
Horizontal pleiotropy test of MR.
| Phenotype | Method | Intercept | SE | p‐Value |
|---|---|---|---|---|
| SLE | MR‐Egger regression | 0.073 | 0.122 | 0.563 |
| SS | MR‐Egger regression | 0.012 | 0.097 | 0.902 |
| PM | MR‐Egger regression | −0.117 | 0.181 | 0.535 |
| DM | MR‐Egger regression | 0.008 | 0.214 | 0.973 |
| SSc | MR‐Egger regression | −0.009 | 0.186 | 0.961 |
| MCTD | MR‐Egger regression | 0.118 | 0.082 | 0.163 |
| RA | MR‐Egger regression | 0.012 | 0.048 | 0.800 |
Abbreviations: DM, dermatomyositis; MCTD, mixed connective tissue disease; MR, Mendelian randomization; PM, polymyositis; RA, rheumatoid arthritis; SE, standard error; SLE, systemic lupus erythematosus; SS, Sjögren's syndrome; SSc, systemic sclerosis.