Figure 3.

Insulin-stimulated glucose uptake in Bckdha deficient cells.A, schematic of experimental design. B–D, levels of ¹³C enriched metabolite from [U-¹³C₆]glucose in cells under basal and insulin-stimulated conditions. E, fold increase in ¹³C enriched metabolite between basal and insulin-stimulated conditions. Data are presented as means ± SD with three cellular replicates. One-way ANOVA with Tukey post hoc analysis for comparison of each group means. ∗p < 0.05, ∗∗p < 0.01, ∗∗∗p < 0.001 indicates comparison to sgControl. ^ap < 0.05 indicates comparison to sgBckdha-1 and ^bp < 0.05 indicates comparison to sgBckdha-2.