Table 5.

Estimated overall effectiveness, direct and indirect effects of the BNT162b2 vaccine on body-system-focused PASC condition clusters in children and adolescents.

	Total effect		Direct effect	Indirect effect
	Vaccine effectiveness (in %) and 95 CI	Relative risk and 95% CI	Relative risk and 95% CI	Relative risk and 95% CI
Delta study in adolescents
Respiratory cluster	97.7% (95.4, 98.9)	0.02 (0.01,0.05)	0.78 (0.44, 1.40)	0.03 (0.01, 0.05)
Musculoskeletal cluster	92.9% (86.0, 96.4)	0.07 (0.04, 0.14)	1.63 (0.88, 3.04)	0.04 (0.02, 0.07)
Cardiac cluster	96.6% (93.3, 98.3)	0.03 (0.02, 0.07)	0.77 (0.21, 2.74)	0.04 (0.01, 0.14)
Syndromic cluster	96.2% (92.5, 98.1)	0.04 (0.02, 0.08)	1.16 (0.58, 2.33)	0.03 (0.01, 0.06)
Gastrointestinal cluster	90.2% (80.5, 95.1)	0.10 (0.05, 0.20)	2.41 (1.47, 3.94)	0.04 (0.02, 0.06)
Omicron study in children
Respiratory cluster	44.3% (16.5, 62.9)	0.56 (0.37, 0.84)	1.87 (1.43, 2.45)	0.29 (0.22, 0.38)
Musculoskeletal cluster	71.3% (56.5, 81.1)	0.29 (0.19, 0.44)	0.49 (0.23, 1.05)	0.57 (0.27, 1.21)
Cardiac cluster	58.3% (36.6, 72.5)	0.42 (0.28, 0.63)	1.17 (0.41, 3.39)	0.34 (0.12, 0.97)
Syndromic cluster	61.9% (42.2, 74.8)	0.38 (0.25, 0.58)	1.13 (0.54, 2.37)	0.33 (0.16, 0.68)
Gastrointestinal cluster	46.7% (18.5, 65.2)	0.53 (0.35, 0.82)	1.63 (0.86, 3.09)	0.32 (0.17, 0.59)
Omicron study in adolescents
Respiratory cluster	87.4% (74.9, 93.7)	0.13 (0.06, 0.25)	0.93 (0.61, 1.41)	0.10 (0.07, 0.16)
Musculoskeletal cluster	76.9% (53.8, 88.4)	0.23 (0.12, 0.46)	0.58 (0.35, 0.95)	0.30 (0.19, 0.49)
Cardiac cluster	27.2% (0.0, 63.5)	0.73 (0.37, 1.00)	2.72 (1.89, 3.91)	0.20 (0.14, 0.29)
Syndromic cluster	73.3% (46.7, 86.7)	0.27 (0.13, 0.53)	0.69 (0.42, 1.13)	0.29 (0.18, 0.48)
Gastrointestinal clustera	–	–	–	–

^aUnreliable estimate due to small number of events.