Subgroup analyses comparing the C-index of the UKB-DRS and the clinical CDRS in internal validation (30% UK Biobank, N = 25,870) and external validation (ESTHER, N = 4383). Notes: Middle-aged is defined as <65 years and older age as ≥65 years. Obesity is defined as a BMI ≥ 30 kg/m2. Abbreviations: CDRS, Cambridge Diabetes Risk Score; UKB-DRS, UK Biobank Diabetes Risk Score; CI, confidence interval.