FIGURE 3.

Serum oligosaccharides. Mean ± SE changes are shown from treatment baseline, defined as the last available value before the first dose of velmanase alfa in the parental study, as the last available value before the first dose in rhLAMAN‐07/‐09 for patients in the placebo arm of rhLAMAN‐05, and as Visit 1 for treatment‐naïve patients in rhLAMAN‐07. The decrease of the mean values between 38.7 and 60.8 months is due to data of only one pediatric patient being available for these time points; this patient had a higher value at treatment baseline and a stronger decrease following treatment than the other patients (Supplementary Figure S1a). X‐axes display the median of each time interval.

SE, standard error.