Table 1. Screening of Conditions for the Pd-Catalyzed Arylation of 11a.

entry	solvent	Base (n equiv)	Conversion to 12af (isolated yield)a
1	methanol	NaOAc (3.0)	>80b (50)
2	methanol	–	dec.c
3	acetonitrile	NaOAc (3.0)	quant. (79)
4	acetonitrile	–	dec.c
5	THF	NaOAc (3.0)	<30%b
6	THF	–	<10%d
7	DMAe	NaOAc (3.0)	<5b
8	DMAe	–	dec.c

^aConversion was determined by TLC and ¹H NMR spectroscopy of the reaction solution.

^bStarting material 11 detected in ¹H NMR spectrum.

^cdec: decomposition; no signals of 12af or 11a visible in ¹H NMR spectrum.

^dSignals for 11a with MOM-ether cleavage observed in ¹H NMR spectrum.

^eDMA: N,N-dimethylacetamide.