Table 2.

Sequence alignment of the mouse 5-HT₃R with the mouse nicotinic α7 receptor and the AChBP. Two sequences are shown. The top sequence is the putative D loop containing W89 and R91 (homologous to W53 and Q55 of the AChBP). The lower sequence shows the putative E loop and contains Y140, Y142 and Y152 (homologous to L102, R104 and M114 of the AChBP).

														53		55
AChBP	E	V	N	E	I	T	N	E	V	D	V	V	F	W	Q	Q	T	T	W	S
5-HT3A	N	V	D	E	K	N	Q	V	L	T	T	Y	I	W	Y	R	Q	Y	W	T
α7 nAChR	D	V	D	E	K	N	Q	V	L	T	T	N	I	W	L	Q	M	S	W	T
						102		104										114
AChBP	V	L	T	P	Q	L	A	R	V	V	S	D	G	E	V	L	Y	M	P	S
5-HT3A	P	N	I	P	-	Y	V	Y	V	H	H	R	G	E	V	Q	N	Y	K	P
α7 AChR	A	T	F	H	T	N	V	L	V	N	S	S	G	H	C	Q	Y	L	P	P