Table 1.
Identifying phosphorylation targets associated with PDAC
| Target | Function in cancer | Reference |
|---|---|---|
| FAM83A | Promote the transcriptional activity of β-catenin | 141 |
| PDE4D | Control the degradation of Camp. | 142 |
| Girdin | Control the cytoskeleton and vascular remodeling | 143 |
| ASPP2 | Regulating cell apoptosis. | 144 |
| WAVE3 | Promote epithelial mesenchymal transition and regulate metastasis. | 145 |
| IER3 | Activate ERK1/2 to support the development of PanIN after pancreatitis. | 146 |
| MUC4 | The transmembrane ligand of ERBB2 maintains its stability on the plasma membrane and enhances activation. | 147 |
| Stattic | Inhibition of STAT3 activation and nuclear translocation. | 148 |
| CAP1 | Regulating actin cytoskeleton and cell migration. | 149 |
| CTDSPL2 | Regulating mitosis and promoting cell movement. | 150 |
| IQGAP1 | articipate in cytoskeleton remodeling, cell migration and intercellular signal transduction. | 151 |