Table 2.
Glycosylation targets associated with PDAC
| Target | Function in cancer | Reference |
|---|---|---|
| ST3Gal1 | Attaching sialic acid to T-antigen, producing sialyl T-antigen | 152 |
| MUC1 | Activating the EGFR-PI3K/Akt signaling pathway and help cancer cells fight anoikis | 153 |
| CA199 | Pancreatic cancer tumor biomarkers | 154 |
| MDH1 | Involved in the interconversion of pyruvate and malic acid in mitochondria | 155 |
| CD44 | Promoting the expression of NANOG in pancreatic cancer cells and facilitate the alteration of CSC feature | 156 |
| MGAT5 | N-glycan branching through adding β1,6-linked N-acetylglucosamine (β1,6-GlcNAc) to an α1,6-linked mannose | 86 |
| TNFR1 | Increased α-2,6-sialylation of TNFR1 inhibits internalization and stabilizes signaling through AKT and NF-κB, conferring resistance to gemcitabine and TNF-induced apoptosis | 157 |