Table 2.

Differentially expressed lipid metabolism genes

Lipid gene	Total cohort mean (n = 184)	Log2 fold change^ (Standard error)	p-value	Adjusted p-value
PCSK9	68.231	2.217 (0.396)	< 0.001***	< 0.001*
DHCR7	253.077	1.023 (0.192)	< 0.001***	< 0.001*
LDLR	676.876	0.848 (0.174)	< 0.001**	< 0.001
ALOX5	23,052.467	0.382 (0.089)	< 0.001*	0.001
PLTP	35.984	0.529 (0.137)	< 0.001	0.003
FDFT1	966.266	0.186 (0.049)	< 0.001	0.004
MSMO1	166.634	0.448 (0.122)	< 0.001	0.005

Differentially expressed lipid metabolism genes in HYPO vs. NORMO patients. Seven out of the 47 a priori selected genes were differentially upregulated in HYPO compared to NORMO patients

PCSK9 Proprotein Convertase Subtilisin/Kexin Type 9; DHCR7 7-Dehydrocholesterol Reductase; LDLR Low-Density Lipoprotein Receptor; ALOX5 Arachidonate 5-Lipoxygenase; PLTP Phospholipid Transfer Protein; FDFT1 Farnesyl-Diphosphate Farnesyltransferase 1; MSMO1 Methylsterol Monooxygenase 1

^ Fold change was calculated using mean of HYPO (n = 87)/mean of NORMO (n = 97)

Significance codes: *p < 0.0001, **p < 0.00001, ***p < 0.000001