Table 3.
Allele and genotype frequencies of GLP-1R SNPs
| SNPs | Genotypes/alleles | Control group [n (%)] | Case group [n(%)] | χ2 | P value | OR (95%CI) |
|---|---|---|---|---|---|---|
| rs3765468 | GG | 62 (81.6) | 48 (63.2) | 6.975 | 0.025 | |
| GA | 14 (18.4) | 26 (34.2) | ||||
| AA | 0 (0.0) | 2 (2.6) | ||||
| G | 138 (90.8) | 122 (80.3) | 6.803 | 0.009 | 2.42 (1.23–4.78) | |
| A | 14 (9.2) | 30 (19.7) | ||||
| rs3765467 | GG | 51 (67.1) | 36 (47.4) | 6.709 | 0.035 | |
| GA | 23 (30.3) | 34 (44.7) | ||||
| AA | 2 (2.6) | 6 (7.9) | ||||
| G | 125 (82.2) | 106 (69.7) | 6.508 | 0.011 | 2.01 (1.17–3.45) | |
| A | 27 (17.8) | 46 (30.3) | ||||
| rs4714210 | AA | 47 (61.8) | 33 (43.4) | 7.642 | 0.022 | |
| AG | 26 (34.2) | 32 (42.1) | ||||
| GG | 3 (3.9) | 11 (14.5) | ||||
| A | 120 (78.9) | 98 (64.5) | 7.848 | 0.005 | 2.07 (1.24–3.45) | |
| G | 32 (21.1) | 54 (35.5) | ||||
| rs10305420 | CC | 57 (75.0) | 51 (67.1) | 1.174 | 0.556 | |
| CT | 17 (22.4) | 22 (28.9) | ||||
| TT | 2 (2.6) | 3 (3.9) | ||||
| C | 131 (86.2) | 124 (81.6) | 1.192 | 0.275 | 1.41 (0.76–2.61) | |
| T | 21 (13.8) | 28 (18.4) | ||||
| rs761386 | CC | 53 (69.7) | 60 (78.9) | 1.690 | 0.194 | |
| CT | 23 (30.3) | 16 (21.1) | ||||
| TT | 0 (0.0) | 0 (0.0) | ||||
| C | 129 (84.9) | 136 (89.5) | 1.441 | 0.230 | 0.66 (0.33–1.31) | |
| T | 23 (15.1) | 16 (10.5) | ||||
| rs761387 | AA | 52 (68.4) | 59 (77.6) | 3.041 | 0.219 | |
| AG | 24 (31.6) | 16 (21.1) | ||||
| GG | 0 (0.0) | 1 (1.3) | ||||
| A | 128 (84.2) | 134 (88.2) | 0.995 | 0.319 | 0.72 (0.37–1.38) | |
| G | 24 (15.8) | 18 (11.8) |
SNPs, single nucleotide polymorphisms; OR, odds ratio; CI, confidence interval