Table 2.
Prediction results of MGMT promoter methylation status using different models
| AUC (95% confidence interval) | Sensitivity (%) | Specificity (%) | Standard error | |
|---|---|---|---|---|
| Single-sequence models | ||||
| T1WIintra model | 0.861 (0.820—0.895) | 82.47 | 76.19 | 0.0228 |
| T1WIprei model | 0.850 (0.809—0.886) | 76.49 | 78.10 | 0.0229 |
| CE-T1WIintra model | 0.867 (0.828—0.901) | 83.67 | 80.95 | 0.0192 |
| CE-T1WIprei model | 0.852 (0.811—0.887) | 79.28 | 81.90 | 0.0205 |
| Two single-sequence combined intratumoral and peritumoral models | ||||
| T1WIintra+prei model | 0.874 (0.631—0.865) | 75.30 | 81.90 | 0.0206 |
| CE-T1WIintra+prei model | 0.889 (0.851—0.920) | 85.26 | 80.95 | 0.0177 |
| Multi-sequence models | ||||
| T1WIintra + CE-T1WIintra model | 0.914 (0.879—0.941) | 83.67 | 83.81 | 0.0155 |
| T1WIprei + CE-T1WIprei model | 0.901 (0.865—0.930) | 86.06 | 84.76 | 0.0215 |
| Multi-sequence combined intratumoral and peritumoral model | ||||
| T1WIintra+prei + CE-T1WIintra+prei model | 0.923 (0.890—0.948) | 86.45 | 87.62 | 0.0141 |
MGMT O6-methylguanine-DNA methyltransferase, AUC area under the receiver operating characteristic curve, T1WI T1-weighted imaging, CE-T1WI contrast-enhanced T1-weighted imaging, intra intratumoral region, prei peritumoral region