Scheme 4. Scope of the Catalytic Hydrogenation of 3,3-Diarylallyl Phthalimides 3.

98% ee was obtained when the catalyst loading was decreased to 0.5 mol %.

2 mol % catalyst loading and 64 h reaction time were used.

Large-scale hydrogenation was performed with Ir–(R,R)-UbaPHOX to yield (R)-5i.

See the SI for the molarity values used in each reaction. All substrates provided complete conversion, except for 5h (Route B; 97%). The ee values were determined by HPLC analysis on a chiral stationary phase.