Table 1. Optimization of Pressure, Solvent, and Catalyst Loading Parameters^a.

entry	catalyst loading [mol %]	PH2 [bar]	solvent	conv. [%]b	ee [%]c
1	5	50	DCM	>99	96
2	5	50	TFT	>99	97
3	5	50	DCE	>99	96
4	5	50	toluene	62	95
5	5	50	EtOAc	3	–
6	5	50	DMC	0	–
7	5	50	PC	0	–
8	5	10	DCM	>99	91
9	5	3	DCM	53	57
10	1	50	DCM	>99	96
11d	1	50	DCM	>99	98

^aThe experiments were carried out at 0.17 M.

^bDetermined by ¹H NMR analysis of the crude reaction mixtures.

^cDetermined by HPLC analysis on a chiral stationary phase.

^dThe starting material was synthesized via Route B (Scheme 3b).