Table 4.
Mendelian Randomization Results
| Outcome | SNPs | Method | OR (95% CI) | P (Effect) | P (Heterogeneity) | P (Intercept) |
|---|---|---|---|---|---|---|
| Susceptibility | 9 | IVW | 0.95 (0.92, 0.99) | 0.022 | 0.951 | |
| MR Egger | 0.99 (0.90, 1.08) | 0.831 | 0.962 | 0.413 | ||
| Weighted median | 0.96 (0.91, 1.00) | 0.082 | ||||
| Simple mode | 0.94 (0.87, 1.02) | 0.163 | ||||
| Weighted mode | 0.96 (0.89, 1.03) | 0.260 | ||||
| Hospitalization | 7 | IVW | 0.86 (0.77, 0.96) | 0.007 | 0.467 | |
| MR Egger | 1.05 (0.82, 1.33) | 0.717 | 0.789 | 0.134 | ||
| Weighted median | 0.88 (0.76, 1.02) | 0.082 | ||||
| Simple mode | 0.92 (0.73, 1.15) | 0.487 | ||||
| Weighted mode | 0.90 (0.76, 1.08) | 0.305 | ||||
| Severity | 10 | IVW | 0.95 (0.83, 1.07) | 0.392 | 0.352 | |
| MR Egger | 0.94 (0.67, 1.32) | 0.726 | 0.266 | 0.961 | ||
| Weighted median | 0.92 (0.78, 1.07) | 0.284 | ||||
| Simple mode | 0.92 (0.71, 1.19) | 0.528 | ||||
| Weighted mode | 0.90 (0.71, 1.14) | 0.419 |
Abbreviations: SNP, single-nucleotide polymorphism; IVW, inverse variance weighted; MR, Mendelian randomization; OR, odds ratio; CI, confidence interval.