Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2024 Dec 24;29:622. doi: 10.1186/s40001-024-02225-4

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc-nd/4.0/.

PMC Copyright notice

Fig. 6 — Immunohistochemistry of skin, brain, and liver specimens of wild-type mice (a①–j① × 100; a②–j② × 400) and NCSTN gene knockout mice (a③–j③ × 100; a④–j④ × 400). Staining for nicastrin (WT-a①/a② and NCSTN gene knockout mice-a③/a④), NICD1 (WT-b①/b② and NCSTN gene knockout mice-b③/b④), and hes1(WT-c①/c② and NCSTN gene knockout mice-c③/c④) in skin tissues mainly in epidermis and hair follicles; in brain tissues, staining for nicastrin (WT-d①/d② and NCSTN gene knockout mice-d③/d④) mainly in neuronal cells and glial nuclear plasma. NICD1 (WT-e①/e② and NCSTN gene knockout mice-e③/e④) mainly expressed in glial nuclear plasma, with a small amount in nerve cells, and hes1(WT-f①/f② and NCSTN gene knockout mice-f③/f④) expressed in neuronal cells, with a small amount in glial nuclear plasma. In liver tissues, staining for nicastrin (WT-g①/g② and NCSTN gene knockout mice-g③/g④), NICD1 (WT-h①/h② and NCSTN gene knockout mice-h③/h④), and hes1(WT-j①/j② and NCSTN gene knockout mice-j③/j④) mainly in the nucleus of hepatic sinusoidal endothelial cells. Compared with wild-type mice (a①–j①, a②–j②), the expression of these proteins in skin, brain and liver tissue was lower in NCSTN gene knockout mice (a③–j③, a④–j④)