Table 1. List of AIPs which affect Aβ production.

AIPs	Aβ production ↑ ↓	Proposed mechanism	References
Caveolin-3	↑	Up-regulate β-secretase-dependent APP cleavage through inactivating G-protein	[26]
FE65	↑	Regulate APP trafficking	[27–29]
GULP1	↑	Reduce APP expression on the cell surface	[30,31]
JIP1	↓	Transport and retain phospho-APP at neurite	[32,33]
LRP	↑	Elevate APP internalization	[34]
Dab1	↑	Increase surface APP expression	[35]
X11	↓	Translocate APP out of detergent-resistant Membrane (DRM) to suppress amyloidogenic processing	[21,36]
Numb	↑	Regulate the sorting of APP into recycling vesicles and decrease the level of cell surface APP	[37]
sorLA/LR11	↓	Reduce surface APP expression by retaining APP in Golgi apparatus and attenuate BACE-dependent APP cleavage	[38]
CHF5074	↓	Reduces the interaction between APP and PS1, lowering γ-cleavage	[39]
		Binds to AICD and reduces its translocation to nucleus	[40]