TABLE 1.
Clinical characteristics of reported neuroleptic malignant syndrome.
| Characteristics | Reports, n (%) |
|---|---|
| Overall | 10,433 |
| Age, years | |
| Median, IQR | 48.00 (31.00,62.00) |
| ≤17 | 593 (5.68) |
| 18–64 | 5,991 (57.42) |
| ≥65 | 1,834 (17.58) |
| Unknow | 2,015 (19.31) |
| Gender | |
| Female | 3,780 (36.23) |
| Male | 5,713 (54.76) |
| Unknown | 940 (9.01) |
| Indications | |
| Schizophrenia | 1,985 (19.03) |
| Unknown | 1,875 (17.97) |
| Bipolar disorder | 836 (8.01) |
| Depression | 714 (6.84) |
| Psychotic disorder | 514 (5.56) |
| Parkinson’s disease | 280 (4.93) |
| Agitation | 274 (2.63) |
| Dementia | 105 (1.01) |
| Anxiety | 90 (0.86) |
| Mania | 87 (0.83) |
| Reported country | |
| United States | 1,727 (16.55) |
| United Kingdom | 942 (9.03) |
| Japan | 923 (8.85) |
| France | 446 (4.27) |
| Canada | 319 (3.06) |
| Spain | 269 (2.58) |
| India | 209 (2.00) |
| Portugal | 207 (1.98) |
| Germany | 202 (1.94) |
| Italy | 199 (1.91) |
| Time to onset, days | |
| Median, IQR | 16.00 (3.00,137.00) |
Abbreviations: IQR, interquartile range.