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. 2024 Dec 11;11:1509168. doi: 10.3389/fmed.2024.1509168

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Copyright © 2024 Lin, Pan, Sun, Wang, Yin, Huo and Guo.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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PCSK9 inhibitor ameliorates bleomycin (BLM)-induced cardiopulmonary remodeling and function (A) Representative images of mice lung sections stained by hematoxylin and eosin (H&E), the frame points to pulmonary arteries. (B) Quantitative assessment of the pulmonary artery lumen to total area ratio. (C) Statistical analysis of the pulmonary arterial wall thickness percentage (WT%). (D) Statistical analysis of the right ventricle hypertrophy index (RVHI). (E) RV hypertrophy shown by H&E staining. (F) Representative right ventricular systolic pressure (RVSP) curve. (G) Statistical analysis of RVSP. *p < 0.05 and ***p < 0.001 versus CON group. ^##p < 0.01 and ^###p < 0.001 versus BLM group.