FIGURE 2.

Inhibition of PCSK9 alleviates fibrotic process and inflammation response in C57BL/6 mice lung (A) Histological and pathological structures of lung section were shown using hematoxylin-eosin staining (H&E), Masson trichrome staining, and Sirius red staining in CON, BLM and SBC groups. Red circles indicate inflammatory cells infiltration. Green arrows indicate fibrotic deposition. (B) Representative immunohistochemical staining for αSMA and COL1A1. (C) Statistical assessment of the α-SMA and (D) COL1A1 positive rate. (E) The level of pro-inflammatory cytokines IL-6, (F) TNF-α and (G) TGF-β from bronchoalveolar lavage fluid (BALF) were quantified by ELISA. ***p < 0.001 versus CON group. ###p < 0.001 versus BLM group.