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. 2024 Dec 11;11:1509168. doi: 10.3389/fmed.2024.1509168

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Copyright © 2024 Lin, Pan, Sun, Wang, Yin, Huo and Guo.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Inhibition of PCSK9 suppresses MLE-12 cell migration ability and fibrotic changes (A) Activity of cell migration was measured by wound healing assay and its quantified data, (B) migration distance and (C) migration area. (D) Representative immunofluorescent staining with αSMA and COL1A1 for MLE-12 cell. (E) Relative immunofluorescent intensity of αSMA and (F) COL1A1 in immunofluorescent images. (G) Typical western blot snapshots of αSMA and COL1A1. (H) Statistical analysis of the protein expression level of αSMA and (I) COL1A1 were observed and measured by western blot and its quantified data. **p < 0.01 and ***p < 0.001 versus CON group. ^#p < 0.05, ^##p < 0.01 and ^###p < 0.001 versus TGF-β group. &p < 0.05 versus 5 μM SBC-115076 group. ns, no significance versus 10 μM SBC-115076 group.