Fig. 2.

Gut microbial dysbiosis in HFD-induced obese mice. Principal component analysis showing noticeably different gut microflora profiles (a). Decreased α-diversity and high Firmicute/Bacteroidetes ratios of the gut microflora of obese mice (b). Changes in relative abundances of gut bacterial families (c). Heatmap showing changes in the richness of gut bacterial genera and less beneficial gut microbiome variety in obese mice (d). HFD consumption affected the relative abundances of 3 gut bacterial species (e). Alterations in the gut microbiome correlated with bone mass and trabecular network loss (f). Data are calculated from 5 mice. Asterisks (*) stand for significant difference (P < 0.05) analyzed by Kolmogorov–Smirnov test and Student t-test