Fig. 1. The framework and working interface of the “mFusion” method.

By using partial least square association to integrate spatial correlations of gene expressions in the human brain with information about neurotransmission and neuroimaging, the mFusion method yields a relevance score for each gene and pathway associated with a mental disorder, facilitating the identification of top-ranked genes and pathways. This fusion method additively provided the potential reasons for neurochemical architectures (neurotransmissions) in PET images influencing gene scores. Subsequent enrichment analysis of top genes identifies biological process and pathways relate to the mental disorder.