Fig. 1. Genomic profiling of RR prostate and head and neck cancer cells.

A Schema of generation and characterisation of radioresistant cell lines with downstream experiment plan (created with Biorender.com). B Total counts of SNV for four RR cell lines included synonymous and non-synonymous SNV. C Distribution of COSMIC mutational signatures identified by all SNVs in each cell line. Only SBS14 is shown for HK1, as other mutational signatures were removed due to overfitting caused by the limited number of SNVs in HK1. D The annotated non-synonymous SNV grouped by the related function in DNA repair, chromatin remodelling, and stemness pathways curated from Gene Ontology libraries. RR radioresistant, SNV single nucleotide variant.