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. 2024 Nov 18;45(6):1235–1248. doi: 10.24272/j.issn.2095-8137.2024.239

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Copyright © 2024 Editorial Office of Zoological Research, Kunming Institute of Zoology, Chinese Academy of Sciences.

This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( http://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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AA participates in the deacylation/reacylation cycle of membrane phospholipids

cPLA2α cleaves glycerophospholipid molecules at the sn-2 position to produce AA. Free AA can be converted to AA-CoA through ACSL4 and immediately re-acylated into membrane phospholipids through LPCAT3. Conversely, bioactive eicosanoids such as leukotrienes (LTs) and prostaglandins (PGs) are synthesized through the lipoxygenase (LOX) and cyclooxygenase (COX) pathways, which participate in the inflammatory response. (Created with BioRender.com). ACSL4: acyl-CoA synthetase long-chain family member 4. LPCAT3: lysophosphatidylcholine acyltransferase 3. AA-CoA: arachidonoyl-CoA.