Skip to main content
. 2024 Nov 18;45(6):1385–1407. doi: 10.24272/j.issn.2095-8137.2024.274

Figure 3.

Figure 3

Timeline of pathological progression in AD transgenic mouse models with reference to human age

Timeline illustrates age at which various pathological features emerge in different transgenic mouse models for AD. Specific transgenic models (Tg2576, APP23, APPswe/PSEN1dE9, 5xFAD, 3xTg, PS19, rTg4510, APP knock-in mice) are listed for clarity. Mouse Age (Months) vs. Human Age (Approximate Correspondence) ( Vermunt et al., 2019) (Preclinical & Prodromal AD; Mild AD dementia; Moderate AD dementia) ( Johnson et al., 2023).