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. 2024 Nov 18;45(6):1385–1407. doi: 10.24272/j.issn.2095-8137.2024.274

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Copyright © 2024 Editorial Office of Zoological Research, Kunming Institute of Zoology, Chinese Academy of Sciences.

This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( http://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Modeling strategies/mutation sites and main phenotypes of principal model organisms used in AD research

Principal model organisms include Caenorhabditis elegans, Danio rerio (Zebrafish), Drosophila melanogaster, Mus musculus (mice), Rattus norvegicus (rats), Tupaia belangeri chinensis (Chinese tree shrews), and Macaca mulatta (macaques). BACE1: beta-secretase 1; UTR: untranslated regions; FTDP-17: frontotemporal dementia with Parkinsonism-17; NFT: neurofibrillary tangle; TREM2: triggering receptor expressed in myeloid cells 2; PSEN1: presenilin 1.