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. 2024 Dec 11;12:1496244. doi: 10.3389/fcell.2024.1496244

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Copyright © 2024 Ercanbrack, Dungan, Gaul, Ramirez, J. DelVecchio, Grass and Wingert.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Pronephros segment development is significantly disrupted in fxn-deficient zebrafish embryos. (A) WISH experiments reveal that fxn is required for the proper formation of the podocytes, multiciliated cells (MCCs), distal early, and distal late tubule. The previously mentioned domains were visualized via the nphs1,cetn4, slc12a1, and slc12a3 probes, respectively. Formation of the proximal convoluted and straight tubules, as assessed by expression of slc20a1a and trpm7 revealed no significant differences between wild-type embryos and fxn morphants. Scale bars = 50 um. Each boxed lateral region in the embryos corresponds to the inset, which shows a dorsal view of that corresponding area for nphs1, slc20a1a, cetn2, and slc12a1 or a lateral view of the corresponding area for trpm7 and slc12a3. (B) Unpaired t-tests of the phenotypes revealed by WISH. ****p < 0.0001.