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. 2024 Oct 2;146(41):28427–28436. doi: 10.1021/jacs.4c09983

Scheme 2. (a, b) Substrate Scope, (c) Synthetic Utilization, and (d) Investigation of Alkyne Activation.

Scheme 2

Standard conditions: 1 (0.8 mmol), 2 (0.4 mmol), Pd(dba)2 (0.02 mmol, 5 mol %), L4 (0.04 mmol, 10 mol %), Cu(MeCN)4PF6 (0.02 mmol, 5 mol %), L5 (0.024 mmol, 6 mol %), HOAc (0.06 mmol), and KOAc (0.8 mmol) in 2-Me-THF (1.0 mL) at 80 °C for 40 h, then NaBH4 was added to reduce the product. Isolated yields are reported. The ee values were determined by HPLC on a Diacel OD-H chiral column.

Without NaBH4.