Table 1. Reaction Development for Asymmetric C–C Amination.

Entrya	L	Solvent	Yield (%)	er
1	L1	MTBE	37	50:50
2	L2	MTBE	4	55:45
3	L3	MTBE	10	30:70
4	L4	MTBE	32	75:25
5	L5	MTBE	34	19:81
6	L6	MTBE	30	72:28
7	L7	MTBE	41	69:31
8	L8	MTBE	76	40:60
9	L9	MTBE	12	75:25
10	L10	MTBE	72	58:42
11	L11	MTBE	10	94:6
12	L11	MTBE	22	95:5
13	L11	cyclohexane	61	90:10
14	L11	mesitylene	69	82:18
15	L11	MeOH	18	53:47
16b,	L11	PhEt	56	91:9
17b,c,	L11	PhEt	86	95:5

^aThe reaction was carried out in 0.10 mmol scale. The yield was determined by ¹H NMR. The er was determined by HPLC analysis.

^b2a (3 equiv) was used.

^cPhEt (0.5 M) was used as the solvent.

^dKO^tBu was used instead of Cs₂CO₃. Isolated yield.