Table 2.
Odds ratio for APS, thrombosis or AID at VWF levels above the 90th percentile.
| Model 1 | Model 2 | |||||
|---|---|---|---|---|---|---|
| ≤ 90th percentile | > 90th percentile | OR (95% CI) | p-value | OR (95% CI) | p-value | |
| Total VWF | ||||||
| Normal controls, n (%) | 84 (90.3%) | 9 (9.7%) | -1- | -1- | ||
| Antiphospholipid syndrome, n (%) | 36 (66.7%) | 18 (33.3%) | 4.67 (1.92 – 11.3) | <0.001 | 3.82 (1.44 – 10.1) | 0.007 |
| Thrombosis, n (%) | 25 (64.1%) | 14 (35.9%) | 5.23 (2.02 - 13.5) | <0.001 | 4.65 (1.64 – 13.2) | 0.004 |
| Auto-immune disease, n (%) | 39 (79.6%) | 10 (20.4%) | 2.39 (0.91 - 6.36) | n.s. | 1.92 (0.68 – 5.37) | n.s |
| Unfolded VWF | ||||||
| Normal controls, n (%) | 84 (90.3%) | 9 (9.7%) | -1- | -1- | ||
| Antiphospholipid syndrome, n (%) | 29 (53.7%) | 25 (46.3%) | 8.05 (3.37 - 19.2) | <0.001 | 8.51 (3.26 - 22.2) | 0.001 |
| Thrombosis, n (%) | 25 (64.1%) | 14 (35.9%) | 5.23 (2.02 - 13.5) | 0.001 | 5.87 (2.07 - 16.7) | 0.001 |
|
Auto-immune disease, n (%) |
35(71.4%) | 14 (28.6%) | 3.73 (1.48 - 9.42) | 0.005 | 3.71 (1.40 – 9.87) | 0.009 |
| VWF pro-peptide | ||||||
| Normal controls, n (%) | 84 (90.3%) | 9 (9.7%) | -1- | -1- | ||
| Antiphospholipid syndrome, n (%) | 33 (61.1%) | 21 (38.9%) | 5.94 (2.47 – 14.3) | <0.001 | 5.19 (1.96 – 13.7) | 0.001 |
| Thrombosis, n (%) | 23 (59.0%) | 16 (41.0%) | 6.49 (2.54 - 16.6) | <0.001 | 6.21 (2.20 – 17.5) | <0.001 |
|
Auto-immune disease, n (%) |
29 (59.2%) | 20 (40.8%) | 6.44 (2.64 - 15.7) | <0.001 | 5.70 (2.21 – 14.7) | <0.001 |
Model 1: Crude; Model 2: adjusted for age and sex. OR, Odds ratio; CI, confidence interval; VWF, Von Willebrand Factor; VWF Ag; VWF Antigen; VWFpp, VWF pro-peptide.