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. 2024 Dec 12;11:1504887. doi: 10.3389/fvets.2024.1504887

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Copyright © 2024 Kong, Wang, Guo, Yang, Lian, Gao, Zhang and Fu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Activation of the Keap1/Nrf2 signaling pathway by baicalin. BMECs were treated with 5 μM RA for 1 h, and baicalin (10 μM) was then added for 18 h before cotreatment with 200 μM H₂O₂ for 6 h. (A) Western blot analysis of Keap1 and Nrf2 protein levels in BMECs. Immunoreactive bands are shown on the left, and quantitative results are shown on the right. (B) Nrf2 mRNA levels in BMECs. (C) Keap1 mRNA levels in BMECs. (D) HO-1 mRNA levels in BMECs. (E) NQO1 mRNA levels in BMECs. *P < 0.05.