Vaccine effectiveness1against COVID-19 hospitalization in SARI patients who received at least one dose of BNT162b2 XBB.1.5-adapted vaccine compared to patients who did not receive any dose of a COVID-19 vaccine in the 2023–2024 autumn/winter season.1Vaccine effectiveness estimates are adjusted for date of symptom onset, age, sex, and number of chronic conditions. 2‘Never vaccinated’ subjects were excluded when calculating the median (IQR) of time since last vaccine dose in the unexposed group (patients who did not receive any dose of a COVID-19 vaccine in the 2023–2024 autumn/winter season). 3The categories “Cancer” and “Immunodeficiency” among chronic conditions are counted as separate types of chronic conditions in all adjusted VE estimates. Here, the VE estimate among participants having “Immunodeficiency or cancer” is provided as a composite. 4The categories “0” and “1” among the number of chronic conditions are counted as separate categories of number of chronic conditions in all adjusted VE estimates. Here, the VE estimate among participants having “0–1”chronic conditions is provided as a composite.