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. 2024 Dec 26;16(1):e13682. doi: 10.1002/jcsm.13682

FIGURE 1.

FIGURE 1

Myofibre hypertrophy, hyperplasia and reduced force generation occur in response to chronic injury in the mdx mouse. (A) Representative immunofluorescence images of transversal tibialis anterior (TA) muscle sections from 13‐, 26‐, 36‐ and 52‐week‐old wild‐type (WT) and mdx mice. LAMININ (red) delineates the myofibres, WGA (green) stains the connective tissues, and Hoechst (blue) labels the nuclei. (B) Quantification of the number of myofibres per transversal TA muscle sections. (C) Mean TA myofibres size using the minimum Feret's diameter. (D) Normalized TA myofibre distribution using the minimum Feret's diameter. (E) Maximum tetanic force and (F) maximum specific force of TA muscles from 13‐, 26‐, 36‐ and 52‐week‐old WT and mdx mice. Scale bar, 100 μm. Data presented as mean values ± SEM. For Panels B–F, two‐way ANOVA with post hoc analysis corrected for multiple comparisons using Sidak's test (*p < 0.05, **p < 0.01, ***p < 0.001). For Panels B–F, n = 4 WT and 4 mdx 13‐week‐old mice, n = 3 WT and 4 mdx 26‐week‐old mice, n = 4 WT and 4 mdx 36‐week‐old mice, n = 4 WT and 4 mdx 52‐week‐old mice. For Panels E and F, n = 6 WT and 6 mdx 13‐week‐old mice, n = 3 WT and 4 mdx 26‐week‐old mice, n = 5 WT and 5 mdx 36‐week‐old mice, n = 4 WT and 5 mdx 52‐week‐old mice.