TABLE 1.

Differences in NO treatment and Clinical outcomes after PSM.

Characteristic	BPD grade Ⅰ N = 46 a	BPD grade Ⅱ-Ⅲ, N = 31 a	p-value
Date of iNO Initiation (hours)	16 (7, 26)	14 (8, 45)	0.893 b
Date of iNO Initiation≤168 h (7 days)	45 (97.8%)	25 (80.6%)	0.015 b
Initial iNO Dose (ppm)	13.0 (8.3, 20.0)	8.0 (5.0, 10.0)	<0.001 b
Maximum iNO Dose (ppm)	15.0 (8.3, 20.0)	10.0 (5.0, 15.0)	0.040 b
Initial iNO Dose/BW	10.3 (5.4, 14.5)	5.7 (3.2, 10.1)	0.004 b
Maximum iNO Dose/BW	11 (6, 15)	7 (4, 12)	0.059 b
Duration of iNO Therapy (hours)	57 (38, 87)	56 (27, 111)	0.975 b
Total Mechanical Ventilation	6 (4, 11)	7 (4, 22)	0.211 b
Total High Frequency Ventilation Time	2.0 (1.0, 4.8)	5.0 (2.0, 7.0)	0.026 b
Total Conventional Mechanical Ventilation	4 (1, 6)	2 (1, 12)	0.642 b
Total Non-invasive Ventilation Time	19 (10, 28)	26 (11, 35)	0.113 b
Total Oxygenation Time	38 (24, 58)	57 (43, 69)	0.002 b
Platelet Count (10^9/L)	153 ± 75	149 ± 68	0.795 b
Prothrombin Time (s)	17 (3, 19)	15 (13, 18)	0.783 b
Fibrinogen Level (g/L)	1.90 (1.40, 2.16)	2.04 (1.63, 2.30)	0.149 b
Activated Partial Thromboplastin Time	71 (66, 76)	68 (58, 79)	0.458 b
Pre-treatment SpO2 (3 h prior)	7.8 (6.0, 10.9)	8.3 (6.6, 10.0)	0.747 b
Post-treatment SpO2 (3 h after)	10 (4, 12)	10 (8, 12)	0.728 b
SpO2 Difference (3 h)	−2.00 (−2.00, −1.00)	−2.00 (−2.00, −1.00)	0.269 b
Oxygenation Index (3 h)	10 (9, 13)	10 (9, 12)	0.228 b
P/F Ratio (3 h)	155 (102, 180)	154 (125, 179)	0.880 b
Oxygenation Index (24 h)	7.7 (5.0, 11.2)	7.6 (4.7, 11.7)	0.839 b
P/F Ratio (24 h)	178 (110, 219)	176 (128, 239)	0.751 b
Oxygenation Index (48 h)	7.8 ± 4.2	8.4 ± 3.7	0.492 c
P/F Ratio (48 h)	184 (143, 240)	164 (114, 213)	0.220 d

Note:

^a Median (Interquartile Range); Mean ± Standard Deviation.

^b Wilcoxon.

^c t-test.

^d Wilcoxon rank sum exact test.