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. 2024 Dec 12;121(52):e2410311121. doi: 10.1073/pnas.2410311121

Fig. 1.

Fig. 1.

The evolutionary history of a protein domain may date back further in time than that of the whole-gene ortholog that it is part of. Multidomain genes 3 and 4 originated around the same time. However, they are made up of two protein domains (blue and orange boxes) that emerged and diverged at different points in time—domain 1 is older than domain 2.