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SYN321. A) The structure of SYN321 includes four components, i.e. diclofenac (in red), NaHA (in blue), a 3‐{[2‐(2‐hydroxyethoxy)ethyl] carbamoyl} propanoic ester molecule (‘linker’, in green) and a succinic ester (in orange). B) Structure of main metabolites upon SYN321 hydrolysis in human plasma and synovial fluid, i.e. diclofenac, diclofenac lactam, and linker.
