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Treatment groups to evaluate the effectiveness of SYN321 in the rat MIA model. All treatments were administered once on study day 11. aGroup size: N = 10. b50 µL per joint. cAnimals in group 2 received diclofenac (25 mg kg−1) administered orally (PO) once on study day 11.
| Groupa | Treatment | Route | Dose level [mg per joint]b |
|---|---|---|---|
| 1 | Saline | IA | N/A |
| 2 | HA + diclofenacc | IA + PO | 0.5 |
| 3 | SYN321 | IA | 0.5 |
| 4 | SYN321 | IA | 0.15 |
| 5 | SYN321 | IA | 0.05 |
