Fig 3.

SERPING1 variants on Family 4 A) Pedigree of Family 4 with persons harboring the variant c.1238T>G p.(Met413Arg) and the Sanger Sequencing confirmation of the Family 4 III,4..+WES and *or ** negative or positive SS respectively B) and C) DynaMut2 protein stability change predictions (ΔΔGstability) were determined by uploading the experimentally derived structure of C1-inhibitor protein to the DynaMut2 server at https://biosig.lab.uq.edu.au/dynamut2/. Dashed lines predict intramolecular interactions. Predicted hydrophobic interactions are shown in green, intramolecular clashes in pink, hydrogen bonds in orange, and carbonyl interactions in blue. (A-B) WT C1-inhibitor protein, (C-D) Met413Arg C1-inhibitor protein.