Table 2.

Genotypic and allelic frequencies of the SCN10A polymorphism, rs6795970, in the IBD and healthy control cohorts

Genotype	Hypoalgesic IBD (n = 84)	Other IBD (n = 332)	Healthy controls (n = 142)	P value
A/A (1073Val/Val)	26 (31.0%)	42 (12.7%)	25 (17.6%)	0.0003
A/G (1073Val/Ala) or G/G (1073Ala/Ala)	58 (69.0%)	290 (87.3%)	117 (82.4%)
Allele
A (valine)	85 (50.6%)	248 (37.3%)	118 (41.5%)	0.007
G (alanine)	83 (49.4%)	416 (62.7%)	166 (58.5%)

Frequencies are listed as number of subjects (% of subcohort). The homozygous genotype (A/A) for the rs6795970 polymorphism and the frequency of this polymorphic allele were each significantly more common in the hypoalgesic IBD cohort.

A, rs6795970 polymorphism(c.3218G>A); G, wild type; IBD, inflammatory bowel disease.