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. 2024 Dec 13;14:1488730. doi: 10.3389/fonc.2024.1488730

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Copyright © 2024 Li, Ma, Wu, Ping, Li and Xu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Three major oncoproteins (E5, E6 and E7) affect multiple potential targets involved in the progression of cervical cancer. E5 upregulates EGFR, thereby regulating the expression of COX2 and VEGF; E6 also affects the EGFR pathway by upregulating the expression of JUK1/2 and c-Jun/AP1. In addition, E6 upregulates OCT4/E6AP, and E6 and E7 upregulate HIF1A-AS2, TBX3, IL-2R and miR-18a/34a. OCT4/E6AP and HIF1A-AS2 both affect p53. In addition, E6 and E7 inhibit PIPOR2 and miR-424, whereas E7 upregulates the expression of PKM2, ultimately regulating the progression of cervical cancer.