Figure 5.

Depression animal models of stress paradigms. Chronic unpredictable mild stress: cold/thermal stimuli, light or dark shifts, strobe light, white noise, paired housing, isolated housing, tail suspension, forced swimming, water/food deprivation, cage tilting/shaking, damp/soiled/changed bedding. Chronic restraint stress: DecapiCones, tubes. Chronic social stress: social defeat, overcrowding cage, social isolation. Maternal separation stress: early weaning, separation from mother and infants. Learned helplessness: inescapable footshocks. Predator stress: predator scent, protected exposure, unprotected exposure. Created using BioRender.com.