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Central anti-inflammatory effect of VNS. (A) VNS changed microglia phenotype from M1 phenotype to M2 type; On the other hand, by activating the a7nAchR receptor, which is widely present in the CNS, the inflammatory cytokines secreted by pro-inflammatory cells are reduced. (B) Maintain the integrity of the blood-brain barrier and prevent the destruction of the central nervous system by inflammatory factors or other substances.
