Figure 1. Structure of JAK2 and PI3KCD. It reveals druggable pocket. (a) Theoretical structure of JAK2 kinase, colored based on secondary structure. (b) Presence of ATP binding pocket (active site) kinase domain of JAK2, green contour representation, showing amino acid residues surrounding the cavity. (c) Crystal structure of PI3KCD kinase, colored based on secondary structure, bound to a reference ligand (85S). (d) protein-ligand interaction analysis showing key amino acid residues of PI3KCD involved in the interactions with 85S.
