Table 3.
Pharmacokinetic parameters of cisplatin in the plasma analyzed by statistical moment principle
| SC (N = 20) |
HITHOC (N = 20) |
HIPEC (N = 20) |
p | |
|---|---|---|---|---|
| AUC0–24h (µg/mL *h) | 3.26 ± 0.56 | 2.57 ± 0.55 | 3.02 ± 0.52 | 0.001 |
| AUC0–∞ (µg/mL *h) | 5.44 ± 3.00 | 4.97 ± 1.42 | 4.30 ± 1.62 | 0.25 |
| MRT0–24h (h) | 7.69 ± 1.49 | 9.63 ± 0.77 | 8.49 ± 0.71 | < 0.001 |
| MRT0–∞ (h) | 25.78 ± 21.66 | 35.67 ± 15.32 | 21.18 ± 13.20 | 0.03 |
| t1/2z (h) | 20.04 ± 15.98 | 25.54 ± 11.62 | 14.58 ± 10.70 | 0.35 |
| Tmax (h) | 1.00 ± 0.00 | 1.38 ± 0.46 | 1.30 ± 0.25 | < 0.001 |
| CLz/F (L/h/kg) | 8.95 ± 3.66 | 8.84 ± 3.02 | 10.29 ± 2.90 | 0.29 |
| Cmax (µg/mL) | 0.69 ± 0.14 | 0.26 ± 0.08 | 0.40 ± 0.15 | < 0.001 |
SC systemic chemotherapy, HITHOC hyperthermic intrathoracic chemotherapy, HIPEC hyperthermic intraperitoneal chemotherapy, AUC area under the concentration–time curve, MRT mean residence time, t1/2z the terminal elimination half- life, Tmax time to peak concentration, CLz/F apparent clearance, Cmax peak concentration