Table 3.

The mediating role of eosinophils and 8-OHdG in the association between exposure biomarkers and FeNO and rhinitis.

Outcome	Mediator	Exposure	Effect	% change per IQR (95%CI)	P value	Proportion mediated
FeNO	Eosinophil	MBzP	Direct	8 (−3, 200)	0.143	37.8%
			Mediated	5 (1, 9)	0.018
			Total	13 (2, 25)	0.015
		MnBP	Direct	15 (1, 258)	0.027	27.9%
			Mediated	5 (0.1, 201)	0.045
			Total	20 (6, 36)	0.005
				OR (95% CI)
Rhinitis	8-OHdG	2,4-D	Direct	0.75 (0.56, 1.01)	0.056	55.4%
			Mediated	1.11 (1.01, 1.21)	0.025
			Total	0.82 (0.61, 1.11)	0.197
		TCPY	Direct	0.81 (0.56, 1.16)	0.239	48.1%
			Mediated	1.07 (1.01, 1.15)	0.034
			Total	0.89 (0.67, 1.19)	0.430
		1-NAP	Direct	0.73 (0.48, 1.12)	0.149	32.7%
			Mediated	1.08 (1.01, 1.16)	0.033
			Total	0.86 (0.65, 1.13)	0.282

CI: confidence interval; IQR: Interquartile range; OR: odds ratio.